STAT2 depletion in USP5-deficient cancer cells significantly reduced upregulated CXCL9 and CXCL10 mRNA, as well as CD86 and HLA-DR protein of cocultured THP1-MΦ (Supplemental Figure 6, A and B); these reductions were rescued by restoring WT-STAT2 but not the Y690A mutant in USP5-depleted cells (Supplemental Figure 6, C–E). This evidence concerns the gene USP5 and cancer.