NOS2 and melanoma: In line with these findings, depletion of tumor-intrinsic Stat2 significantly reduced intratumoral CXCL9+ macrophages (Figure 4K), iNOS+ macrophages, and IFN-γ+TNF-α+CD8+ T cell infiltration in Usp5-deficient B16 melanomas in vivo (Figure 4L and Supplemental Figure 6, F and G).