Knockout ofthe Rag2 gene prevents maturation of T and B lymphocytes, allowingsubcutaneous xenograft of human cell lines for assessment of anticancerdrug activity. Here, we report the outcome of studies evaluating theengraftment of 8HUM/Rag2–/– with hE to facilitate P. falciparum infection, and of infection of immunocompetent8HUM with P. berghei, for the supportof antimalarial drug discovery. Here, RAG2 is linked to infection.