IL2RG and infection: In the future, it would be interesting to determine whethergenetic deletion of Il2rg in 8HUM/Rag2–/– renders this line sufficiently immunocompromised to accept hE engraftment.As this specific modification, with resulting suppression of the interferonresponse, was a key factor in permitting high rates of engraftmentand infection in NSG mice, any furthereffort to develop an 8HUM-based P. falciparum infection model should prioritize this same genetic deletion aheadof any further attempt to ablate the immune system by alternativemeans such as antibody blocking, chemical treatment, or surgery.