RAG2 and infection: To determine whether 8HUM/Rag2–/– could be engrafted with hE and subsequently infected with P. falciparum, we tested a protocol used routinelyat GSK during evaluation of the efficacy of New Chemical Entities(NCEs). In a typical study, administrationof hE to NSG mice once daily by intraperitoneal (i.p.)injection leadsto displacement of approximately 50% of murine erythrocytes by approximately10 days, allowing infection with P. falciparum.