This study highly reveals that TGF-β1 facilitates the communication between senescent mesothelial cells and fibroblasts, which is controlled via β-catenin, underscoring the pivotal role of the β-catenin-Drp1-TGF-β1 axis in peritoneal fibrosis. The gene discussed is TGFB1; the disease is Peritoneal Fibrosis.