All these patients were outside the current APASL HBV treatment guidelines, 9 (60%) met with the AASLD guidelines with twice upper limit of normal ALT levels (35 U/L for men and 25 U/L for women compared to 40 U/L in APASL and EASL guidelines) which also include the risk factor of HCC family history, 13 patients (87%) met the latest EASL HBV treatment guidelines. Here, GPT is linked to hepatocellular carcinoma.