NLRP3 and colorectal carcinoma: We propose the following hypothesis: Vinegar processing can alter the properties of frankincense water extract and enhance its accumulation in the colon; the accumulated water extract of PF then enriches butyric-producing gut microbiota and increases intestinal butyric levels; subsequently, butyric inhibits the NLRP3 inflammasome pathway, promotes the polarization of M1-type TAMs and suppresses their pyroptosis, ultimately exhibiting superior anti-CRC efficacy compared to RF water extract.