Based on functional differences, TAMs can be divided into two phenotypes: M1-type TAMs (marked by CD86, iNOS, and CD169), which secrete pro-inflammatory cytokines to enhance anti-tumor immunity; and M2-type TAMs (marked by CD206, CD163, and CD204), which promote tumor invasion and immune evasion [9, 10]. Here, MRC1 is linked to neoplasm.