Pyroptosis is a pro-inflammatory programmed cell death mediated by the NLRP3 inflammasome and caspase-1, which can impair the anti-tumor function of M1-type TAMs: activated NLRP3 triggers the cleavage of caspase-1, leading to gasdermin D (GSDMD)-dependent membrane rupture and the release of interleukin (IL)-1β/IL-18, which ultimately resulting in a reduction in M1-type TAMs [11]. Here, GSDMD is linked to neoplasm.