AKT1 and neoplasm: The convergence of JMJD6/EHF on TGF-β/SMAD and AKT/ERK cascades explains the potent effect on tumor metastasis, as these pathways coordinately regulate EMT, cell motility, and survival in the circulation.46–48 While our data establish JMJD6 as a critical IR-induced effector, the precise mechanism driving its upregulation warrants further investigation.