CSCs, defined by robust self-renewal and multi-lineage differentiation, are recognized drivers of treatment resistance and failure.37 Radiation induces the transformation of non-stem cancer cells into CSCs, thereby conferring resistance to RT.9,10 This process, often termed cellular plasticity, is increasingly recognized as a major adaptive response to cellular stress, and our experimental results identified JMJD6 as a central epigenetic mediator of this transition. This evidence concerns the gene JMJD6 and cancer.