The initial cytoreduction of RT provides a selective pressure that eliminates therapy-sensitive cells, while creating a permissive niche that favors the expansion of pre-existing or newly induced resistant clones.36 A potential mechanism underlying JMJD6-mediated radioresistance in lung cancer involves the intrinsic presence or the post-IR emergence of CSCs. This evidence concerns the gene JMJD6 and lung carcinoma.