EHF is a member of the epithelial-specific ETS (ESE) transcription factors,44, and has been identified as a key driving factor for the progression of colorectal cancers and the maintenance of intestinal stem cells.45 In lung cancer, EHF overexpression is associated with poor patient prognosis.34 Our study suggested that the increased EHF expression in NSCLC cells could, in part, be attributed to JMJD6 upregulation following IR treatment. This evidence concerns the gene EHF and colorectal cancer.