The TME refers to the cellular and molecular milieu surrounding the tumor or cancer stem cells and includes diverse cellular populations, cytokines, and structural components such as the extracellular matrix, CD4+ T cells, CD8+ T cells, B cells, and M1-type or N1-type neutrophils act to suppress CRC progression, whereas M2-type tumor-associated macrophages and N2-type tumor-associated neutrophils promote immune evasion and accelerate disease development [3]. The gene discussed is CD4; the disease is neoplasm.