In conclusion, this study constructed the hsa_circ_0089131-miR-378a-3p-TP53-PI3K-Akt/MAPK signaling pathway ceRNA regulatory network related to breast cancer metastasis and preliminarily clarified the important role of hsa_circ_0089131, miR-378a-3p and TP53, which laid a bioinformatic foundation for an in-depth understanding of the molecular mechanism of breast cancer. This evidence concerns the gene AKT1 and breast cancer.