A relatively mild [15, 16, 60, 61] and slowly progressing [15] atrophy, characterized by a predominantly frontal rather than temporal epicenter of GM alterations [15, 60], has previously been reported also in bvFTD associated with a C9orf72 mutation and in presymptomatic C9orf72 carriers [62]. The gene discussed is C9orf72; the disease is Atrophy.