This “frontotemporal‐plus motor” pattern of structural damage for ALS‐FTD supports its relative proximity to bvFTD, suggesting it represents a distinct TDP43‐related phenotype rather than a late‐stage evolution from purely motor ALS [5], whose functional and structural alterations tend to remain limited to motor networks in the absence of cognitive and behavioral impairment [65]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.