The combined syndrome of ALS‐FTD, which has been found to be driven by a C9orf72 mutation in approximately 20%–30% of cases [15, 16], provides a shortcut for translating clinical observations into neuropathological insights, as there is a reliable correspondence between this clinical presentation and the presence of TDP‐43 aggregates [11, 16, 17, 18]. This evidence concerns the gene TARDBP and frontotemporal dementia.