Taken together, these findings suggest that ALS‐FTD, driven by TDP‐43 type A and B [8], may present an intermediate degree of limbic hub degeneration, more pronounced than that typically associated with FTLD‐tau pathology [73], but less pronounced than the degeneration linked to TDP‐43 type C in semantic variant primary progressive aphasia, with a possible modulation by C9orf72. This evidence concerns the gene MAPT and frontotemporal dementia.