ITM2B and neoplasm: Specifically, the ITM2B1‐243 truncation protein interacts with APP to inhibit amyloid beta peptide (Aβ) production, the ITM2B244‐266 truncation protein prevents Aβ aggregation, and full‐length ITM2B promotes Aβ clearance.[15] In fact, ITM2B cleavage also occurs in various tumor cell lines, but the functions of ITM2B truncations remain unknown.