ITM2B and aceruloplasminemia: In humans, ITM2B gene mutations lead to two types of autosomal dominant dementia, namely, familial British dementia and familial Danish dementia, characterized by progressive dementia, cerebellar ataxia, and other clinical symptoms.[15, 18, 19] Although the broad expression of ITM2B and its cleavage in tissues have been demonstrated, its physiological functions, particularly in cancer development, have been ignored and need further investigation.