Hyperuricemia effectively promoted tumor growth and Ki67 expression in ITM2B‐expressing allografts, whereas these promoting functions of hyperuricemia were attenuated in ITM2BI115A‐expressing allografts (Figure 7H,I), confirming the essential role of ITM2B cleavage in mediating the aggravating effect of hyperuricemia on RCC growth. The gene discussed is ITM2B; the disease is neoplasm.