To verify whether hyperuricemia aggravates RCC tumor growth through inducing ITM2B cleavage, we separately utilized ITM2B‐expressing and ITM2BI115A‐expressing Renca cells to inoculate orthotopic allografts, and the mice were subsequently administered with potassium oxonate and hypoxanthine for 18 days to induce hyperuricemia. Here, ITM2B is linked to neoplasm.