Considering the well‐established protumoral effects of IL‐6 signaling on tumor growth,[33, 35] it can be concluded that ITM2B truncation‐dependent migrasomes transfer active caspase‐7 from RCC cells to macrophages, where active caspase‐7 promotes IL‐6 secretion and subsequently activates IL‐6 signaling in RCC in a feedback manner, thereby exacerbating RCC growth. Here, ITM2B is linked to neoplasm.