On the basis of these findings, the combination of potassium oxonate and hypoxanthine to induce hyperuricemia in vivo further verified that hyperuricemia indeed utilizes the ITM2B truncation–migrasome axis to aggravate RCC growth, highlighting the importance of ITM2B truncation‐induced migrasomes under physiological and pathological conditions. Here, ITM2B is linked to renal cell carcinoma.