We unexpectedly found that active caspase‐7 (i.e., c‐CASP7, cleaved caspase‐7), rather than full‐length caspase‐7 (CASP7), was enriched in migrasomes derived from both human and mouse RCC cells (Figure 5A; Figure S5D, Supporting Information), suggesting a preferential sorting mechanism for active caspase‐7 by ITM2B truncation‐enriched migrasomes. This evidence concerns the gene CASP7 and renal cell carcinoma.