In overexpression plants, GmMKK1 and GmMPK4A were bound with GmMEKK2 and phosphorylation was inhibited, leading to the activation of SUMM2‐related downstream defence responses, such as the up‐regulated expression of the SA‐induced defence gene PR1 and ROS accumulation, ultimately resulting in autoimmunity (Figure 7A). The gene discussed is TMEM37; the disease is Autoimmunity.