FURIN and cancer: An activationof the gp160 of HIV was also demonstrated by PC7, consistent withfurin and PC7 being the only basic PCs present in lymphatic cellsand tissues., Furin is also described as targetfor the personalized treatment of certain cancer types, whereas othertypes of cancer do not benefit from an inhibition of furin., An additional furin substrate is the epithelial sodium channel (ENaC).Its activation enables the inward conductance of Na+ ionsfrom the airway surface liquid (ASL) into epithelial cells.