Improved attention and verbal memory (apt and cvlt) in lp299v group; decreased kynurenine (kyn) concentration; increased 3hkyn: kyn ratio; interaction for anthranilic acid (aa) concentration; no significant change in TNF‐α, IL‐6, IL‐1b, and cortisol concentrations. Improvement in cognitive functions; biochemical changes related to depression; no significant change in proinflammatory cytokines and cortisol. Overall, lp299v supplementation might have enhanced cognitive functions and modulated biochemical parameters related to depression without affecting proinflammatory markers. The gene discussed is TNF; the disease is major depressive disorder.