TNF and depressive symptom measurement: Improved attention and verbal memory (apt and cvlt) in lp299v group; decreased kynurenine (kyn) concentration; increased 3hkyn: kyn ratio; interaction for anthranilic acid (aa) concentration; no significant change in TNF‐α, IL‐6, IL‐1b, and cortisol concentrations. Improvement in cognitive functions; biochemical changes related to depression; no significant change in proinflammatory cytokines and cortisol. Overall, lp299v supplementation might have enhanced cognitive functions and modulated biochemical parameters related to depression without affecting proinflammatory markers