The above findings provide a systematic revelation of the multilayered regulatory mechanisms of the CCNE1‐PARP16 axis across spatiotemporal dimensions—at the cellular level, it maintains the survival of dopaminergic neurons via the ferroptosis pathway, and at the tissue level, coordinates neuroglial interactions via the NRG3‐ERBB4 signaling pathway, thus creating a synergistic protective network targeting PD pathology. The gene discussed is PARP16; the disease is Parkinson disease.