The results showed that the total effect of CCNE1 on PD (βall = −0.362, p = 0.032) is mediated by three key ferroptosis‐related proteins—ADP‐ribosylation factor 6 (ARF6), cytochrome b5 reductase 1 (CYB5R1), and Poly (ADP‐ribose) polymerase family member 16 (PARP16), with the mediating effect of PARP16 being the strongest (mediated proportion 44.17%). Here, CYB5R1 is linked to Parkinson disease.