This would also be in line with AQP measurements, which confirmed lower overall activity in DM as well as significant downregulation of membranous AQP3, AQP5 and AQP6 expression, all linked to cell migration and tumor progression in the context of cancer and NSCLC [31, 36, 70, 71], with AQP3 considered an unfavorable lung adenocarcinoma marker [72]. Here, AQP6 is linked to lung adenocarcinoma.