For instance, in an analysis of 4398 familial breast cancer cases and 4316 controls, five single-nucleotide polymorphisms (SNPs) (rs7895676, rs2912781, rs10736303, rs2912778 and rs2981582) in FGFR2 were found to be significantly associated with breast cancer [14]. The gene discussed is FGFR2; the disease is breast carcinoma.