With the exception of a slight increase in CEA, all tumor markers, including the cancer antigen 15 − 3 (CA15-3), squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21 − 1), neuron-specific enolase (NSE), pro-gastrin-releasing peptide (ProGRP), alpha-fetoprotein (AFP), and soluble interleukin-2 receptor (sIL-2R), were within normal ranges. The gene discussed is ENO2; the disease is neoplasm.