Asthma can have two major endotypes categories to be considered: T-helper type 2 cell high endotype (T2-High) which uses Interleukins 4 and 13 (IL-4, IL-13) causing production of immunoglobulin E (IgE) and IL-5 to bring eosinophils, T-helper type 2 cell low endotype (T2-Low) which uses IL-1, IL-8, IL-17, and Il-23 causing neutrophilic inflammation with normal serum and sputum eosinophils level [70]. This evidence concerns the gene IL4 and asthma.