Considering that single nucleotide polymorphisms (SNPs) in the upstream regulatory region of Golph3l gene may affect its promoter activity and expression level, and that multiple noncoding variants, including promoter/enhancer variants, were associated with thoracic aortic aneurysms and dissections,[43] we ought to know whether there exist several functional SNPs in the region upstream of Golph3l transcription start site. Here, GOLPH3L is linked to thoracic aortic aneurysm.