Together, these findings provide clear evidence that genetic variant of Golph3l rs6700022 A‐to‐C, which creates a novel binding motif for Klf5, is associated with high expression of Golph3l in patients with AD and AAA, and this variant may be useful in predicting the development and progression of vascular remodeling‐related diseases. This evidence concerns the gene KLF5 and Alzheimer disease.