GOLPH3 and neurodegenerative disease: Conversely, overexpression of Golph3 results in a more dispersed Golgi.[21, 22] Despite the existing evidence showing that the Golph3/Golph3l pathway is activated in response to DNA damage and plays a role in the pathophysiology of neurodegenerative disease, the molecular link between Klf5, Golph3l, and Golgi morphology alteration in the context of the aortic remodeling has not been investigated.