CD40LG and autoimmune polyendocrinopathy: The recent 2023 ACR/EULAR classification criteria [3] (not recommended now to establish the diagnosis of APS in everyday practice) proposed to use a different strict approach leading to a 25% reduction of subjects with arterial thrombosis classified as APS patients due to high cardiovascular disease (CVD) risk, isolated presence of IgM antibodies or both [10].