Daubeuf suggested that GGT mRNA in hepatocellular carcinoma cells is predominantly of subtype B. Sheen suggested that the GGT I mRNA subtype B is related to the serum AFP level in tumor foci, degree of differentiation of the tumor cells, residual postoperative infiltration, postoperative infiltration of the tumor, postoperative recurrence, and postoperative survival, and monitoring GGT I mRNA is an important indicator for predicting whether recurrence occurs after surgery. This evidence concerns the gene AFP and hepatocellular carcinoma.