Serum GGT in combination with other tumor markers, such as AFP, PIVKA‐II, GP73, and the GGT/AST ratio, can improve the diagnostic sensitivity of HCC, especially in the early stage, small volume individuals with good liver function, and GGT may also reflect mitochondrial dysfunction after HCV eradication, which is a risk factor for the development of hepatocellular carcinoma [113]. This evidence concerns the gene GOLM1 and hepatocellular carcinoma.