In pancreatic ductal adenocarcinoma (PAAD), TXNDC12 interacts with GGT7 through cysteine residues in its active site to activate GGT7, resulting in an increase in GSH, a decrease in GSSG, a decrease in reactive oxygen species (ROS) and malondialdehyde (MDA), and an increase in glutathione peroxidase 4 (GPX4) expression. Here, TXNDC12 is linked to pancreatic adenocarcinoma.