EMP3 and GGT5 are LARS regulated tumor suppressors in breast cancer, LARS a specific tRNA synthetase, LARS downregulation promotes breast tumor formation, GGT5 expression is subject to LARS‐mediated translational regulation, and in breast cancer, GGT5 overcomes chemo‐resistance non‐cell‐autonomously, and Passarelli, M. et al. Knockdown of GGT5 can enhance organoid growth, which further emphasizes its role as a tumor suppressor [57]. The gene discussed is LARS1; the disease is breast cancer.