GGTLC1 is a protein‐coding gene initially named GGTL6, later renamed GGTLA4, and changed to GGTLC1 in 2008. It has been found that GGTLC1 is highly expressed in endometrial cancers, and this high expression negatively correlates with immune cell infiltration and DNA methylation, and promotes tumor progression by regulating the TGF‐β/Smad signaling pathway. Knockdown of GGTLC1 inhibited the proliferation and migration of endometrial cancer cells and induced cell cycle arrest and apoptosis. GGTLC1 may be a promising target for endometrial cancer therapy [72]. The gene discussed is GGTLC1; the disease is neoplasm.