The significance of baseline serum GGT in the diagnosis of hepatocellular carcinoma is as follows: serum GGT > 200 U/L can predict the risk of hepatocellular carcinoma in patients with hepatitis B and has some significance in the suspicion of early hepatocellular carcinoma; serum GGT > 450 U/L and serum GGT are significantly greater in primary hepatocellular carcinoma patients than in cirrhosis patients, which is important for the diagnosis of hepatocellular carcinoma. This evidence concerns the gene GGTLC3 and hepatocellular carcinoma.