Taken together, the available data suggest that the GGT7 genes, GGT I mRNA B isoforms, s‐GGT, and GGT‐II isoforms are potentially valuable for early diagnosis, prognostic assessment, and selection of therapeutic targets for HCC; however, the relationship between the GGT mRNAs and GGT genes is complex and regulated by a variety of factors, and there is a lack of validated protein coding activity of the GGT7 genes, GGT I mRNA B isoforms, s‐GGT, and GGT‐II isoforms, which have not yet been demonstrated to be related in terms of function and regulatory mechanisms. This evidence concerns the gene GGTLC3 and hepatocellular carcinoma.