The significance of baseline serum GGT in the diagnosis of hepatocellular carcinoma is as follows: serum GGT > 200 U/L can predict the risk of hepatocellular carcinoma in patients with hepatitis B and has some significance in the suspicion of early hepatocellular carcinoma; serum GGT > 450 U/L and serum GGT are significantly greater in primary hepatocellular carcinoma patients than in cirrhosis patients, which is important for the diagnosis of hepatocellular carcinoma. The gene discussed is GGTLC3; the disease is Cirrhosis.