The identified immune and inflammatory signatures, particularly the upregulation of cytokines including CXCL10, IL‐6, TNFSF9, and HLA‐B, may reflect both intrinsic tumor biology and EBV‐induced immunomodulation, all of which warrant further investigation into EBV–host interactions in NPC pathogenesis. Here, CXCL10 is linked to neoplasm.