RNA sequencing of NPC cells showed that METTL14 upregulated or downregulated several genes associated with immunity and inflammation, including TNF, IFN, IL, and MHC class I. RNA interference‐mediated knockdown of METTL14 revealed its regulatory effects on TNF‐related genes (e.g., TNFRSF12A, TNFRSF9, TNFSF15), IFN‐induced genes (e.g., PSMC6, PSMD1, PSMA2, PSMA3, PSMB2), and IL‐related genes (e.g., CCL5, IL1B, IL32, IL7R, IL6, IL7, CXCL2). This evidence concerns the gene PSMA3 and nasopharyngeal carcinoma.