Moreover, extracellular IFI16 promotes TLR4‐mediated inflammation via LPS binding [78], sustains STING expression to activate IFN‐γ signaling in melanoma [79], and exerts antitumor effects by inducing apoptosis, inhibiting neovascularization, and enhancing macrophage recruitment [80]. The gene discussed is TLR4; the disease is melanoma.