IRS1 and nasopharyngeal carcinoma: To refine further, we performed an analysis that intersected significantly downregulated genes in C666‐1 cells as compared to NP69 cells with significantly upregulated genes in 5‐8F (highly metastatic NPC cells) versus 6‐10B (low metastatic NPC cells) within the GSE15903 dataset and identified 314 overlapping genes (among others IFIH1, IRS1, TNFSF10) (Figure 2F).