This study reveals that METTL14 overexpression in NPC cells upregulates MHC class I genes (HLA‐A, B, C, −E), whereas METTL14 silencing broadly downregulates MHC class I expression, including HLA‐A, B, C, F, −G, and TAP1. The gene discussed is METTL14; the disease is nasopharyngeal carcinoma.