The dual role of Wnt/β-catenin is noteworthy: (i) promoting the rapid proliferation of Lgr5+ ISCs by regulating cell cycle progression via cyclin D1 [19, 23–25], and (ii) exerting anti-apoptotic effects in extra-intestinal tissues [26, 27]—a mechanism that remains underexplored in porcine inflammatory bowel disease. The gene discussed is LGR5; the disease is inflammatory bowel disease.