Similarly, in clear-cell renal cell carcinoma (ccRCC), NAT10 acts through ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 (ANKZF1) to increase the nuclear localization of yes1-associated transcriptional regulator (YAP1), thereby driving tumor progression and lymphangiogenesis [75]. The gene discussed is YAP1; the disease is nonpapillary renal cell carcinoma.