CD4 and nasopharyngeal carcinoma: In nasopharyngeal carcinoma (NPC), the same family of HMGB2, high mobility group box 1 (HMGB1), the direct target of dead box helicase 5 (DDX5), is upregulated by the NAT10-mediated ac4C modification of DDX5, which inhibits the T-cell immunity of CD4 + and CD8 + T cells and promotes NPC progression [85].