In addition, NAT10 can specifically upregulate the expression of the nucleic acid acetyl coenzyme A (acetyl-CoA) to drive chemoresistance in hepatocellular carcinoma through the acetylation of ATP citrate lyase (ACLY) at K468, and K468 is required for the nuclear localization of ACLY [100]. Here, ACLY is linked to hepatocellular carcinoma.