A recent report in osteosarcoma (OS) revealed that NAT10 enhances the stability of activating transcription factor 4 (ATF4) mRNA through ac4C modification, upregulates asparagine synthetase (ASNS) expression, and facilitates tumor cell proliferation and metastasis through Asn-mediated protein and nucleic acid synthesis [97]. This evidence concerns the gene ATF4 and osteosarcoma.