To explore baseline predictors of nonresponse, we performed univariable logistic regression analysis with Firth’s penalized likelihood, including variables such as age, sex, body weight, total IgE, cedar/cypress-specific IgE, nasal eosinophil status, dosing regimen, and comorbidities (asthma, CRSwNP, CRSsNP). This evidence concerns the gene IGHE and asthma.