Apparent mineralocorticoid excess (AME) is a rare autosomal recessive disorder caused by deficiency of 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2), the enzyme responsible for converting active glucocorticoids such as cortisol and corticosterone to their inactive metabolites, cortisone and 11-deoxycorticosterone, in the kidney [1, 2]. The gene discussed is HSD11B2; the disease is Increased circulating aldosterone concentration.