Scindia et al. demonstrated in a murine ischaemia–reperfusion injury model that elevated serum hepcidin confers renoprotection, and exogenous hepcidin administration restores iron homeostasis and attenuates renal injury [19, 37, 38].These findings align with our results and underscore the diagnostic relevance of hepcidin in early AKI detection. This evidence concerns the gene HAMP and acute kidney injury.