In contrast, genes involved in stress response, transcriptional regulation, and host interaction, including integrase/recombinase XerD (K04763), HTH-type transcriptional regulator or antitoxin HipB (K15773), type IV secretion system protein TrbJ (K20266), molecular chaperone DnaK (K04043), chromatin remodeling protein SMARCAL1 (K14440), acyl homoserine lactone synthase LuxI (K22954), lysozyme (K01185), and antitoxin YxxD (K21494), were significantly enriched in NAFLD-enriched viral genomes. The gene discussed is LYZ; the disease is metabolic dysfunction-associated steatotic liver disease.