TP53 and Miyoshi myopathy: We assessed the impact of HR genetic abnormalities, such as t(4;14), t(14;16), t(14;20), gain/amp 1q, del(1p), del(17p) and TP53mut, and their co-occurrences in a real-world cohort, revealing that patients with a multi-hit TP53 constitute the poorest prognostic group within the whole MM cohort.