PTHLH and hypercalcemia disease: As was true for OSRC-2 cells, RXF393 cells induced cachexia and hypercalcemia in subcutaneous xenograft assays and these two phenotypes were reversed by PT2399 (Extended Data Fig. 6e–h) and prevented by CRISPR KO of PTHLH without commensurate changes in tumor growth (Extended Data Fig. 6i–n).