CD68 and neoplasm: Interestingly, CD68+ cells had also accumulated around the periphery of the primary tumour and had a distinct morphology from the intratumour CD68+ cells (Fig. 5a), with smaller and more uniform cells typical of macrophages at the periphery and larger, multinucleated CD68+ cells present in the tumour centre with a phenotype more typical of osteoclasts (Fig. 5a).