CD68 (3.42 ± 1.16% of primary tumour was positive via IHC) (Supplementary Fig. 7b) immunoreactivity identified the presence of cells from the monocyte lineage, suggesting an accumulation of macrophages and osteoclasts within the OS tumour, particularly at the tumour-bone interface (Fig. 5a, b). The gene discussed is CD68; the disease is neoplasm.