CSF1R-LD is also commonly known as adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and formally unifies two previously distinct conditions, hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD), under a single diagnostic umbrella due to their shared genetic basis and overlapping clinical features378. This evidence concerns the gene CSF1R and Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia.