Further analysis showed that USP13 knockdown arrested DLBCL cell survival (Supplementary Fig. 1A, B) and genetic or pharmacological manipulation of USP13 markedly affected DLBCL cell migration (Supplementary Fig. 1C, D), indicating the prominent role of USP13 in DLBCL tumorigenesis. Here, USP13 is linked to diffuse large B-cell lymphoma.