HES1 and neoplasm: Accordingly, the dissected specimens from tumor tissues demonstrated further reduction of USP13 and Ran expression as well as the proliferative marker Ki-67, the ferroptosis mediator NQO1 and ALOX12, and increase in the expression of HES1, a Notch pathway marker, and BIRC3, a marker in the NF-κB pathway in combination groups compared with the single treatment group (Fig. 6D).