Overexpression of the DUB USP13 has been identified in gastric [10], kidney [11], lung [12, 13], ovarian [13], breast [14] and cervical [15] cancers functioning as oncoprotein or tumor suppressor depending on specific cancerous context, and regulates the turnover of several key players in cancers including MCL-1 [13, 15], MYC [12], FASN [16], ZHX2 [11] and PTEN [14]. Here, ZHX2 is linked to cancer.