NEK7 and Hepatic fibrosis: When NEK7 is depleted, the stability of complex II deteriorates, and its activity is abnormally increased, which leads to over-reduction of coenzyme Q and an increase in membrane potential, thereby promoting the reverse transfer of electrons to complex I. Increased ROS generation in this process may explain why NEK7 deficiency in hepatocytes aggravates CCl4-induced liver fibrosis.