The average DFS and OS of patients with ICC with low-SVEP1 expression were 18.82 months (18.82 ± 2.16) and 36.98 months (36.98 ± 3.76), respectively, which were significantly shorter than those of patients with high SVEP1 expression (35.44 months, 35.44 ± 5.93, and 65.42 months, 65.42 ± 8.11). This evidence concerns the gene SVEP1 and intrahepatic cholangiocarcinoma.