Multivariate analysis revealed total bilirubin (TBIL) ≥ 21 μmol/L (p < 0.001), positive satellite nodes (SN, p = 0.009), and low-SVEP1 expression (p = 0.002) as independent risk factors for DFS in our cohort of 113 ICC cases (Fig. 2F and Supplementary Table 3). Here, SVEP1 is linked to intrahepatic cholangiocarcinoma.