Additionally, Gene set enrichment analysis (GSEA) confirmed that low SVEP1 expression was associated with poorer clinical prognosis of patients with CCA based on mRNA data from three other GEO datasets: GSE132305 (n = 220, p = 0.046), GSE89749 (n = 120, p = 0.039), and GSE45001 (n = 20, p = 0.033) (Fig. 1H and Supplementary Fig. 1A–C). The gene discussed is SVEP1; the disease is cholangiocarcinoma.