Combined analysis of PPA1 expression and the clinical data revealed that the CRC patients in PPA1-high group exhibited higher T stage (p = 0.0033; Fig. S1G), lymph node metastasis rate (p < 0.0001; Fig. S1H), and TNM stage (p < 0.0001; Fig. S1I), whereas PPA1 expression showed no correlation with age (p = 0.2318), gender (p = 0.2337), or M stage (p = 0.2862) of patients (Table S2). Here, PPA1 is linked to colorectal carcinoma.