PPA1 and colorectal carcinoma: To investigate the effects of PPA1 on the biological functions of CRC cells, we transfected HCT8 and HCT116 cells, which had the highest expression of PPA1, with ShRNA knockdown lentivirus for PPA1 and screened three stable cell lines including the control group (Sh-NC) and the knockdown group (Sh1-PPA1, Sh2-PPA1) cell lines.