BCL2 and breast cancer: In addition to mediating PTX resistance in breast cancer cells via the regulation of YB1-Bcl-2 signal axis, TRIM25 is reported to promote the nuclear translocation of transcription factor EB (TFEB) and transcription of autophagy-related genes by increasing ubiquitination of TFEB, thereby decreasing chemosensitivity to PTX in TNBC [18].