KLRD1 and Miyoshi myopathy: As NK cell activation is under the control of opposite activating and inhibitory signals provided by target cells, we turned our attention on examining the possible impact of Pol I inhibitors on the expression of classical and non-classical HLA-I molecules, which represent ligands for inhibitory KIR and CD94/NKG2A receptors, respectively, as an event that could explain the differential ability of CX-5461 and BMH-21 to enhance NK cell activation against MM.