MYC and neoplasm: Gene Set Enrichment Analysis (GSEA), performed via the Xena “blitzGSEA” web-based bioinformatics platform, demonstrated that differentially expressed genes between ISS stage III and stage I encompassed canonical tumor progression hallmarks as expected (e.g., MYC targets, E2F targets, and mTORC1) alongside hallmarks related to RiBi and ribosome maturation (Fig. 1B, C).