As shown in Fig. 2A, treatment of SKO-007(J3) human MM cells with nanomolar concentrations of CX-5461 or BMH21, induced alterations in nucleolar morphology as evidenced by confocal microscopy with the formation of nucleophosmin (NPM1) rings and condensation of Fibrillarin (NPM), typical features of NSR. This evidence concerns the gene FBL and Miyoshi myopathy.