RPS6KB1 and Miyoshi myopathy: In this setting, treatment of MM cells with CX-5461 did not markedly affect the protein expression levels of the kinases ATR and S6K under identical experimental conditions, while a little decrease in the expression level of AKT and S6K was observed in RPMI-8226 cells in the presence of BMH-21 (Supplementary Fig. 13A–F).