NPM1 and Miyoshi myopathy: As shown in Fig. 2A, treatment of SKO-007(J3) human MM cells with nanomolar concentrations of CX-5461 or BMH21, induced alterations in nucleolar morphology as evidenced by confocal microscopy with the formation of nucleophosmin (NPM1) rings and condensation of Fibrillarin (NPM), typical features of NSR.