Indeed, CX-5461, more effectively than BMH-21, enhanced the expression of NK cell-activating ligands (MICA, MICB, PVR/CD155, NECTIN-2, and B7-H6) on MM cell lines, and this upregulation was partially corroborated in patient-derived CD138+ MM cells (Fig. 4 and Supplementary Figs. 5 and 7). Here, MICB is linked to Miyoshi myopathy.