Finally, to contextualize TBK1/IKKε KOs with previously described sensitizing mutations affecting the same signaling pathway, we compared our samples to RNF31 KOs and observed that TBK1 and IKKε depletion sensitized tumor cells to T cell attack to an even greater extent than RNF31 depletion with these T cell donors (Fig. 4C). Here, IKBKE is linked to neoplasm.