TBK1 and melanoma: We generated polyclonal functional TBK1 KOs in two different melanoma cell lines (BLM, D10) and observed that loss of TBK1 alone is able to sensitize cells to T cell challenge in some melanoma cell lines (Fig. 4A, B), while knocking out both TBK1 and IKKε is required in others (Fig. 4C).