Later, this approach was used in animal models to rescue various mutations causing retinal dystrophies in genes such as PDEB [81], PRPH2 [82, 83], MERTK [84], RHO [85], CNGB1 [86], SPATA7 [87], RP2 [88], PDE6A [89], and PDE6B [90]. The gene discussed is PDE6B; the disease is inherited retinal dystrophy.