Suppressor of cytokine signaling 2 (SOCS2), a negative regulator of GH signaling, has been implicated in growth regulation but has not been previously studied in pediatric CKD.<h4>Methods</h4>In this cross-sectional study, we assessed serum SOCS2 concentrations in 55 children with CKD (stages 2-5) and 27 age- and sex-matched healthy controls using a high-sensitivity ELISA. The gene discussed is SOCS2; the disease is chronic kidney disease.