SOCS2 concentrations were higher in short-statured children, and ROC analysis showed acceptable diagnostic performance for predicting short stature (AUC 0.78, 95% CI 0.64-0.91; 79.5% sensitivity, 68.8% specificity).<h4>Conclusions</h4>Circulating SOCS2 levels are elevated in pediatric CKD and independently associated with growth impairment, suggesting its potential link to GH resistance, which is typical of CKD. This evidence concerns the gene SOCS2 and chronic kidney disease.