PGP and cancer: BCNCs with optimal formulation were characterizedin terms of colloidal stability, particle size, and zeta potential.Using the optimized formulation, Pgp-siRNA/Dox-coloaded BCNCs wereevaluated for cellular uptake, Pgp silencing efficacy, endosomal/lysosomalescape, and MDR reversal efficacy in MCF-7 and MCF-7/ADR cancer cells.In addition, their MDR reversal capability was demonstrated in anotherMDR cancer cell line, MES-SA/Dx5.