Some of these non-canonical pathways include mitogen-activated protein kinase signaling, which has been found to increase GLI transcriptional activity and nuclear localization, as well as promote GLI protein stability in cancers from a variety of tissues, including pancreatic tumors (15, 52, 53, 54, 55, 56, 57). The gene discussed is WNK2; the disease is pancreatic neoplasm.