The variant rs78689026 (NC_000006.11:g.30740038G>A), located at the intronic region of the HCG20 gene, showed the lowest p‐value and a trend towards an association with increased risk of severe COVID‐19 (OR = 3.05; 95% CI = 1.57–5.92; p = 0.001). This evidence concerns the gene HCG20 and COVID-19.