Results of a comparative study between mild and severe COVID‐19 cases involving 306 individuals have suggested risk associations with severe COVID‐19 for the HLA‐DPB1*13:01 allele (OR = 3.42, 95% CI = 1.05–11.16, p = 0.041) and the HLA‐B*39 allele group (OR = 3.26, 95% CI = 1.16–9.13, p = 0.024), although statistical significance was lost after FDR adjustment for multiple comparisons (adjusted p > 0.05). This evidence concerns the gene HLA-DPB1 and COVID-19.