So far, generic questionnaires have mainly been used for HRQoL assessment in VWD.<h4>Aims</h4>To assess generic and disease-specific HRQoL in adult VWD patients and compare HRQoL with the general German population.<h4>Methods</h4>Patients presenting with a personal or family history of bleeding and von Willebrand factor (VWF)-specific laboratory parameters were enrolled in the WIL-QoL study. The gene discussed is VWF; the disease is von Willebrand disease (hereditary or acquired).