TNF and neoplasm: E3-19 K, a protein that suppresses MHC class 1 expression, its deletion enhances immune recognition and promotes CTL mediated clearance of infected tumor cells [72]; E3-10.4 K/14.5 K which form the Receptor Internalization and Degradation (RID) complex; their deletion restores TRAIL- and Fas-mediated apoptosis in infected tumor cells resulting in increased apoptosis of infected tumor cells when deleted; and E3-14.7 K, which blocks TNF-α-induced apoptosis, its deletion sensitizes tumor cells to TNF-mediated cell death.