EIF2AK2 and neoplasm: This deletion also improves immune recognition of infected cells [46], (iii) Deletion of ICP47, a viral protein that inhibits antigen presentation, restores MHC class 1 expression and enhances visibility of infected tumor cells to CTLs, (iv) Early expression of US11, typically expressed late in wild-type HSV-1 infection to counteract PKR, ensures efficient viral replication even in tumors with intact PKR responses broadening the therapeutic scope of T-VEC.