Similarly, the elevated levels of ICAM-1 (Intercellular Adhesion Molecule – 1) and decay-accelerating factor (DAF/CD55) in cancers like breast cancer, multiple myeloma, and melanoma allow coxsackievirus (e.g., coxsackievirus A21) to induce oncolysis within these malignancies. This evidence concerns the gene ICAM1 and melanoma.