BDNF and Alzheimer disease: We analyzed next the effects of EOD feeding regimen on the number of PV-INs and BDNF/TrkB signaling pathway in the brain of 5xFAD mice, a well-characterized and widely used transgenic model of AD with robust and early Aβ plaque deposition and concomitant neuroinflammation, particularly in the cortex and hippocampus [49, 50].