MAPT and cerebrovascular disorder: The moderating effect of sex was not studied in biomarkers of other pathologies such as cerebrovascular disease measured with white matter signal abnormalities (WMSA) on MRI.6 These WMSA have shown increased frequency in cognitively unimpaired females in the general population.50 Altogether, future research should investigate sex-specific pathology findings in SCD, taking into consideration the role of different genetic profiles and biomarkers beyond amyloid-beta and tau.