Severe symptoms: invasive or positive-pressure oxygen requirement, acute kidney injury (Cr >1.5× upper limit normal for age or estimated glomerular filtration rate [eGFR] <60), elevated aspartate/alanine transaminase (AST/ALT) ratio >2× normal, new elevation international normalized ratio (INR) >1.3, and altered mental status. This evidence concerns the gene GPT and acute kidney injury.