INS and type 1 diabetes mellitus: Data from the DCCT (29) and UnitedKingdom Prospective Diabetes Study (UKPDS) (30) indicate that hyperglycemia is the main driver, withadditional contributions from dyslipidemia, hypertension, genetic predisposition,obesity (particularly in T2D), low insulin and C-peptide levels, and autoimmunity(notably in T1D) (7,27,28).